Skip to main content
Home

YONDELIS® Information for Patients and Caregivers

Banner Big Arrow Icon
Now Approved Icon

YONDELIS® Information for Patients and Caregivers


Experience an infusion with YONDELIS®


YONDELIS® is for patients with leiomyosarcoma or liposarcoma, two types of soft tissue sarcoma. YONDELIS® is given by intravenous (IV) infusion over 24 hours. Watch this video to learn what to expect during a typical YONDELIS® infusion experience. Ask your doctor about other possible administration options.



YONDELIS® is a prescription medicine used to treat people with liposarcoma or leiomyosarcoma that:

  • cannot be treated with surgery or has spread to other areas of the body, and
  • who have received treatment with certain other medicines.
    It is not known if YONDELIS® is safe and effective in children.
Divider Image
Divider Image

Who should not receive YONDELIS®?

You will not be given YONDELIS® if you have had a severe allergic reaction to YONDELIS® or any of the ingredients in YONDELIS®. The active ingredient in YONDELIS® is trabectedin. Other ingredients in YONDELIS® are potassium dihydrogen phosphate, sucrose, phosphoric acid, and potassium hydroxide.

Divider Image

What should I tell my healthcare provider before receiving YONDELIS®?

Before receiving YONDELIS®, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver or kidney problems.
  • are pregnant or plan to become pregnant. YONDELIS® can harm your unborn baby. You should not become pregnant during treatment with YONDELIS®.
    • Females who are able to become pregnant should use an effective form of birth control during treatment with YONDELIS® and for 2 months after your last dose of YONDELIS®.
    • Males should use an effective form of birth control when having sex with female partners who are able to become pregnant, during your treatment with YONDELIS® and for 5 months after your last dose of YONDELIS®.
  • are breastfeeding or plan to breastfeed. It is not known if YONDELIS® passes into your breast milk. You should not breastfeed during treatment with YONDELIS®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Divider Image
Bottle Icon

How will I receive YONDELIS®?

  • YONDELIS® is given by an intravenous (IV) infusion into a vein over 24 hours. To help avoid irritation at the site where it is infused, YONDELIS® is given to you into a large vein through a type of IV line called a central venous line.
  • YONDELIS® is usually given every 3 weeks.
  • Your healthcare provider may decrease your dose or delay doses if you have certain side effects. If you have any side effects that are severe, your healthcare provider may stop your treatment with YONDELIS®.
  • Before each treatment with YONDELIS®, you will receive a steroid medicine to help reduce your risk of getting certain side effects.
  • Your healthcare provider will decide how long you will continue treatment with YONDELIS®.
  • Your healthcare provider may do certain tests while you are receiving YONDELIS® to check you for side effects, and to see how well you respond to the treatment.
Divider Image
Doctor Icon

What should I avoid during treatment?

Avoid grapefruit and grapefruit juice during treatment with YONDELIS®.

Divider Image

What are the possible side effects of YONDELIS®?

YONDELIS® may cause serious side effects, including:

Severe infections due to decreased white blood cells. Decreased low white blood cell count is common with YONDELIS®, but it can also lead to severe infections and death. Your healthcare provider may need to decrease your dose of YONDELIS®, delay or stop your treatment, if your white blood cell count is too low or you get a serious infection. Call your healthcare provider right away if you develop fever or other signs of infection.

  • Severe muscle problems (rhabdomyolysis). YONDELIS® can cause muscle problems that can be severe and lead to death. Tell your healthcare provider right away if you have severe muscle pain or weakness.
  • Liver problems, including liver failure. Tell your healthcare provider right away if you get:
    • yellowing of your skin and whites of your eyes
    • pain in your upper right stomach-area (abdomen)
    • nausea
    • vomiting
    • generally do not feel well
    • problem with concentration
    • confusion
    • sleepiness
  • Heart muscle problems, including heart failure. Your healthcare provider will do a test to check your heart function before you start YONDELIS®, and during treatment. If you develop heart muscle problems or heart failure during treatment with YONDELIS®, your doctor may stop your treatment. Tell your healthcare provider right away if you develop new chest pain, shortness of breath, tiredness, swelling of your legs, ankles, or feet, or heart palpitations.
  • Leakage of YONDELIS® out of your vein during the infusion. If YONDELIS® leaks into the tissues around your infusion site, it can cause damage and death of tissue cells around the infusion site. You may need to have surgery to remove any dead tissue. Tell your healthcare provider right away if you see any YONDELIS® leaking out of your vein or around the catheter during your infusion, or if you notice any redness, swelling, itching or discomfort at the infusion site at any time.
  • Some people have had allergic reactions to YONDELIS®. Some of these reactions were severe. Your healthcare provider may need to stop your treatment with YONDELIS®, and may give you medicines to treat the allergic reaction. Signs of an allergic reaction can include: difficulty breathing, chest tightness, wheezing, swelling of the lips, or skin rash.

The most common side effects of YONDELIS® include:

  • nausea
  • tiredness
  • vomiting
  • constipation
  • decreased appetite
  • diarrhea
  • swelling of your hands, ankles, or feet
  • shortness of breath
  • headache
  • decreased red cell count (cells which carry oxygen in the blood). Tell your healthcare provider if you feel more tired than usual or look pale.
  • decreased platelet cell counts (cells which help blood to clot). Tell your healthcare provider if you bruise easily or have bleeding.
  • changes in liver and kidney function blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of YONDELIS®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Divider Image

Is there anything else I should tell my healthcare provider before receiving YONDELIS®?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Divider Image

Is there a patient support program available?

Carepath Logo Image

Janssen CarePath is a comprehensive support system to help patients start and stay on therapy. Janssen CarePath Case Coordinators can offer you support, education, and resources related to YONDELIS® (trabectedin). Below are the many ways we can help you at every step.

Access Tool Icon

ACCESS tools

Help you start therapy by making treatment accessible with services and resources that include:

  • Insurance coverage explanation
  • Cost support options
  • Dedicated Case Coordinators
Education Tool Icon

EDUCATION tools

Help keep you informed about your disease and treatment with services and resources that include:

  • Educational brochures
  • Web-based resources
  • Education about and referral to independent organizations that provide assistance with costs associated with travel to and from treatment
Adherance Tool Icon

ADHERENCE tools

Help you stay on therapy with useful tools and reminders that include:

  • Personalized, live appointment reminders
  • Access to the Care4Today Mobile Health Manager App‚ providing medication reminders and more

Please call Janssen CarePath at 1-844-YONDELIS (1-844-966-3354), Monday through Friday, 8:00 AM to 8:00 PM ET, and speak to a Janssen CarePath Case Coordinator today.

Request a call from a Janssen CarePath Case Coordinator

Janssen CarePath Case Coordinators are available Monday through Friday from 8 AM to 8 PM ET to give you a call at your convenience. They will answer your questions about the services provided by Janssen CarePath. Fill out and submit the form to request a call.

The information you provide will only be used by Janssen Products, LP, our affiliates, and our service providers to provide you information about Janssen CarePath and YONDELIS®. Our Privacy Policy governs the use of the information you provide. By providing the information and selecting the SUBMIT button, you indicate that you read, understand, and agree to these terms.

you would like to receive a call:
of day you would like to receive a call:

*Required field.

Divider Image

Can I get help paying for my treatment?

If you have commercial or private insurance

If eligible, you pay $20 for each infusion. Subject to a $15,000 maximum annual program benefit for each calendar year. Not valid for patients enrolled in Medicare, such as Medicare Part D, or Medicaid. Other restrictions may apply.

Janssen CarePath Savings Program rebates* are determined by medication cost only, and not the cost associated with IV infusion.

For additional details including complete eligibility and restrictions, please visit www.CarePathSavingsProgram.com.

*This is a reimbursement of out-of-pocket expense and not considered income.

If you have Medicare

Janssen CarePath can refer you to the Medicare Savings Program to discuss eligibility and program benefits. To learn more about eligibility and how the Medicare Savings Program can help you pay for Medicare Part B products, visit www.medicare.gov/Contacts/staticpages/msps.aspx and select the appropriate state.

If you are uninsured

The Johnson & Johnson Patient Assistance Foundation, Inc. (JJPAF) is committed to providing access to uninsured patients who lack the financial resources to pay for their medicines. If you need YONDELIS® and are uninsured and unable to pay for your medicine, please contact a JJPAF program specialist at 1-800-652-6227, 9:00 AM to 6:00 PM ET, or visit the foundation website at JJPAF.org to see if you might qualify for assistance.

For a comprehensive list of cost support programs related to YONDELIS®, visit JanssenPrescriptionAssistance.com/YONDELIS.

Divider Image
Contact Mobile Icon

Where can I learn more?

For more information about Janssen CarePath, call 1-844-YONDELIS (1-844-966-3354), Monday through Friday, 8:00 AM to 8:00 PM ET.



INDICATION

What is YONDELIS® (trabectedin)?

YONDELIS® is a prescription medicine used to treat people with liposarcoma or leiomyosarcoma that:

  • cannot be treated with surgery or has spread to other areas of the body, and
  • who have received treatment with certain other medicines.

It is not known if YONDELIS® is safe and effective in children.

Important Safety Information

Indication

INDICATION

What is YONDELIS® (trabectedin)?

YONDELIS® is a prescription medicine used to treat people with liposarcoma or leiomyosarcoma that:

  • cannot be treated with surgery or has spread to other areas of the body, and
  • who have received treatment with certain other medicines.

It is not known if YONDELIS® is safe and effective in children.

  • Share to Twitter
  • Share to Linked In
  • Share to Facebook
  • Share to Google Plus

© Janssen Products, LP 2016. All rights reserved. The use of the information on this site is subject to the terms of our Legal Notice. Please see our Privacy Policy. This site is published by Janssen Products, LP which is solely responsible for its contents. This site is intended for use by healthcare professionals in the United States and its territories. Janssen Products, LP recognizes that the Internet is a global communications medium; however, laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. The Prescribing Information included here may not be appropriate for use outside the United States.

Site last updated: November 2016

Error Message Icon

Please hold your device
in the portrait position.